Tesofensine

GLPs are much better in my opinion, but tesofensine definitely helps with appetite. It works as a triple monoamine reuptake inhibitor, so it affects serotonin, norepinephrine and dopamine instead of the GLP pathway. I’d be very careful mixing it with antidepressants or other mental health medications.

Thanks for the info. I’m not taking any mental health medications.

That removes one concern, but I’d still keep an eye on heart rate and blood pressure. The human trial started as low as 250mcg, so I definitely wouldn’t jump straight into a larger dose.

If we're talking pure weight loss it is pretty mid. I'd stick with Tirz or Reta. People who can't handle needles or need the convenience of a capsule look at Tesofensine. Also, the sides seem way more common with that compound.....heart rate (+~7 bpm at 0.5 mg, more at 1 mg) plus dry mouth, insomnia, and constipation. It's a pass from me.

Tesofensine is completely different from Reta, semaglutide or tirzepatide. It suppresses appetite through the central nervous system rather than the gut-hormone pathway. The human data is real, but there isn’t nearly as much of it. The Phase 2 trial showed meaningful weight loss, but also an increase in heart rate at the 0.5mg dose. That cardiovascular piece is what would stop me from treating it like a simple GLP replacement.

As a person that hates needles, this sounds interesting me. Can I pair it with Reta?

The cardiac part settles it for me. I’m going to stick with TRT, HGH and a small dose of Reta. Appetite suppression isn’t worth adding something that might cause a different set of problems.

You can absolutely pair them, just keep track of your resting heart rate as they both elevate it. I know you hate needles, but Cagri + Reta is the superior combo. Or maybe even Elora if your wallet can handle it.

“Does it work?” is usually the wrong question. The better question is how it works and what you’re trading for the result. Phen-fen worked. Meth kills your appetite too. That doesn’t mean the side effects are worth it. If appetite suppression is the only goal, I’d rather stay with the option that has the better-known risk profile.