Tesamorelin question

TStarted by Trooper

I'm debating between getting CJC-1295 vs Tesa, but is there a reason to get the blend with Ipa. Looking around, it's like everyone carries CJC with Ipa, but then I see Tesa and that rarely comes with Ipa. I'm just wondering why that is, or is one better than the other? Just seems weird to me that two GH signalers don't just automatically come with Ipa blended.

Replies

Excuse my long winded reply, but a lot to cover here and I'll go into the specifics for anyone else that later finds this thread with the same questions.

Ipa isn’t a GHRH analog. CJC no DAC and Tesamorelin both hit the GHRH receptor. Ipa hits the ghrelin receptor (GHS-R1a). Same pituitary cell, two different inputs. That’s why GHRH + Ipa is synergistic. I've seen a few blends out there that have Tesa + CJC + IPA and that's just a dumb blend. Two GHRH analogs in one vial would is redundant. This is a vendor honeypot if you ask me.

CJC no DAC is a short GHRH(1-29). Half life is like ~30 min. Solo it’s kind of mid. Pair it with Ipa and you get the pulse people actually want, and the doses line up (both in the low hundreds of mcg), so vendors just standardized a 5/5 or 10/10 blend. In short, you never want CJC alone; always buy it in a blend with Ipa and always no DAC.

Tesa is a stabilized GHRH(1-44). It was developed and approved as monotherapy (Egrifta, 2mg daily). The Phase 3 VAT data is Tesa alone — and if memory serves ~15% visceral drop, IGF-1 up, not much happening to subcutaneous fat or scale weight. Research shops just sell Tesa the way the drug exists, solo. Also the doses don’t mix cleanly. Tesa is in mg, Ipa is in mcg. Premixing that is a dumb fixed ratio, and Tesa is already the expensive vial so they’re not dying to throw Ipa in for free.

You can run Tesa + Ipa as two separate pins if you want the dual-receptor bump. People do it. It’s just not a common factory blend and you're getting expensive at that point. Most people honestly go with the CJC/ IPA route because of cost.

Better depends on what you mean. Tesa has actual human outcome data for visceral/liver fat. CJC/IPA is cheaper and probably a bigger raw GH pulse because two receptors. Bigger pulse ≠ automatically better VAT loss. If I was chasing the thing tesa actually has trials for I’d run Tesa solo. If I just wanted a cheap nightly pulse stack I’d do CJC no DAC + Ipa. That's my 2¢.

T
Replying to @Peptide Protocols

Appreciate the well thought out reply. I was leaning towards Tesa just because it's well known and has all that trial data. Sounds like CJC no DAC + Ipa is the way to go and I'll save some cash.

Replying to @Trooper

If you ask around you'll get people advocating for both sides of the coin. I personally researched CJC no DAC w/ IPA and I liked it. Ran for 8 weeks, but you can do 12 weeks. Since I was experimenting with Reta as well, you actually don't want to follow the common protocol which is to dose in the evenings before bed. Reason being is that Reta slows gastric emptying, which means you're not as fasted as you need to be and thus it stunts the GH pulse. Instead you want to pin it after waking up and then don't eat for at least 1hr after. I also always warn people that adverse reactions can happen with CJC. It's rare, but does happen so just keep it on you radar. Make sure to come back and posts your thoughts once you have completed a cycle. It helps everyone out.

If anyone is reading this thread and considering Tesamorelin, I'd suggest you take a look at Virtus Peptides. They are running a deal right now on a 10-pack and each vial comes out to $29.90. That's a great price and comes with free shipping. Only catch is that it is pre order and doesn't ship for about another week.